Integrated ADMET-PK Function for MedChem Decision Support

The bioavailability and pharmacokinetics of any molecule depends on its absorption, metabolism and distribution. Our ADMET-PK & Bioanalytical Support teams are fully integrated with our medicinal chemistry projects to provide fast and efficient decision support for rapid hit seeking, hit-to-lead, lead optimization, candidate selection, and investigational toxicity. In support of preclinical and clinical development, SCYNEXIS performs analyses of compounds in a wide variety of matrices. SCYNEXIS can also customize protocols and reports based on therapeutic areas and customer’s specifications. Our ADMET-PK & Bioanalytical Team leadership consists of experienced veterans from large pharmaceutical development companies and organizations including GSK, RTI and Eli Lilly.

Success with SCYNEXIS

Our team works in state-of-the-art facilities with access to a comprehensive suite of high-end biological assays and bioanalytical instrumentation. We have successfully developed and delivered numerous assays to our clients’ drug discovery and development programs including:

• CNS/brain tissue exposure for Stage II Human African Trypanosomiasis (HAT)
• Ocular tissue distribution of novel drug candidates for dry eye indications
• Prodrug and parent monitoring to improve bioavailability and release profiles

In Vitro ADMET Capabilities