Research Capabilities  Medicinal Chemistry

SCYNEXIS Medicinal Chemistry: Making Molecules that Matter

The complex process of transforming a hit into a clinical candidate requires a broad range of technical skills and capabilities. SCYNEXIS incorporates Medicinal Chemistry, Computational Chemistry, Analytical Chemistry and Bioanalytical Chemistry into SCYNEXIS Research Teams that focus these disciplines to meet specific project demands. SCYNEXIS supports these efforts with a secure and chemist-friendly data handling system that allows both SCYNEXIS and customer scientists to view results and make informed decisions.

SCYNEXIS’ medicinal chemistry group has a reputation equaling the best in the industry. Our team has the size and experience to handle projects of any complexity in a wide range of therapeutic areas. The Research Team leaders are knowledgeable scientists with years of industry experience. They coordinate and communicate key activities and drive resources to achieve success. The teams are enabled with SCYNEXIS’ powerful proprietary technologies such as KIT™ Kinase Inhibitor Technology , HEOS Software Suite and MEDCHEM-FACTORY®;.

• HEOS® (Hit Explorer Operating System): Comprehensive web-based chemical information management software
• ADME/PK: Bioavailability, stability and Cyp450 information is available from our in-house capability
• KIT™ (Kinase Inhibitor Technology): Leverages structural information to define binding modes
• Computational Chemistry: Predictive physiochemical properties, homology modeling and receptor docking, QSAR
• MEDCHEM-FACTORY®;: High-throughput synthesis and purification

Selected Achievements: Taking a hit (5 micromolar) to a 20 nanomolar enzyme inhibitor in a four-month time frame Optimizing a non-bioavailable natural product into a highly orally effective drug candidate Addressing stability and solubility liabilities in a series leading to an accepted backup compound

Copyright © 2007. SCYNEXIS, INC