The Effect of pH on the In Vitro Antifungal Activity of SCY-078
E. Larkin, C. Hager, L. Long, N. Isham, S. Barat, K. Borroto-Esoda, S. Wring, D. Angulo, M. Ghannoum
IDSOG 2017
August 2017
Vaginal Concentrations of SCY-078, a Novel Glucan Synthase Inhibitor, Following Oral Administration in Mice
S. Barat, K. Borroto-Esoda, S. Wring, D. Angulo
IDSOG 2017
August 2017
![SCY-078, a Novel Intravenous and Oral Antifungal Agent, Demonstrates Extensive Tissue Distribution in Rats Following Single Intravenous Infusions and Oral Doses of [14C]SCY-078](https://d1io3yog0oux5.cloudfront.net/_f87b5f9ff47ba600f9b3c5f623964fbb/scynexis/db/385/2585/pdf_thumbnail.jpg "SCY-078, a Novel Intravenous and Oral Antifungal Agent, Demonstrates Extensive Tissue Distribution in Rats Following Single Intravenous Infusions and Oral Doses of [14C]SCY-078")
SCY-078, a Novel Intravenous and Oral Antifungal Agent, Demonstrates Extensive Tissue Distribution in Rats Following Single Intravenous Infusions and Oral Doses of [14C]SCY-078
S. Wring, E. Solon, D, Watson, S. Barat, D. Angulo
ASM Microbe 2017
June 2017
Assessment of the In Vitro Antifungal Activity of SCY-078 Against a Panel of Susceptible and Resistant, Clinical Candida Isolates from Europe
K. Borroto-Esoda, S. Birchall, C. B. Moore, D. Angulo
ASM Microbe 2017
June 2017
Susceptibility Testing of SCY-078 Against Candida Isolates Obtained from a Clinical Study of Oral SCY-078 vs. Oral Fluconazole in Subjects with Moderate to Severe Vulvovaginal Candidiasis Demonstrates no Resistance Development
K. Borroto-Esoda, D. Angulo, E. Larkin, I.Salem, L. Long, S. Helou, M. Ghannoum
ASM Microbe 2017
June 2017
Lack of an Effect of SCY-078, a Novel Antifungal Agent on QTc Interval in Healthy Subjects
G. Murphy, B. Darpo, T. Marbury, M. Hyman, D. Angulo
ASM Microbe 2017
June 2017
Pharmacokinetics and Pharmacodynamics in Patients from a Phase 2, Multicenter, Open-Label, Randomized, Comparative Study of Oral SCY-078 vs. Standard-of-Care Following Initial Intravenous Echinocandin Therapy in the Treatment of Invasive Candidiasis (including Candidemia) in Hospitalized Non-neutropenic Adults
D. Angulo, S. Helou, S. Wring, S. Barat
ASM Microbe 2017
June 2017
Pharmacokinetics of SCY-078 following Intravenous Administration in Rabbits: Implications for Treatment of Experimental Invasive Pulmonary Aspergillosis
V. Petraitis, R. Petraitiene, B.W. Maung, F, Khan, K. Borroto-Esoda, D. Angulo, S. Barat, T. J. Walsh
ASM Microbe 2017
June 2017
In vitro Interaction between SCY-078, Echinocandins and Azoles against Susceptible & Resistant Candida spp. Determined by the Checkerboard Method
K. Borroto-Esoda, B. Scorneaux, D. Angulo, S. Helou
ASM Microbe
June 2017
CYP-mediated Drug Interaction Profile of SCY-078, a Novel Triterpene Glucan Synthase Inhibitor (GSI)
G. Murphy, M. Hyman, M. Willett, D. Angulo
ASM Microbe 2017
June 2017