Mr. Macdonald joined the board in November 2014 and became Chairman in June 2015. Mr. Macdonald served as the President and Chief Executive Officer and member of the board of directors of Tetraphase Pharmaceuticals, Inc. (Nasdaq: TTPH) from January 2008 to August 2019. From August 2003 until January 2008, Mr. Macdonald served as Executive Vice President of Operations of Idenix Pharmaceuticals, Inc. (Nasdaq: IDIX), a biopharmaceutical company. From 1981 to 2003, he served in various positions at Merck & Co., Inc. (NYSE: MRK), most recently as the Vice President for Anti-Infective and Hospital Products. Mr. Macdonald received an Honors Degree in biochemistry from Dundee University in Dundee, Scotland.

Mr. Anido joined our Board in January 2019. He served as Chairman and Chief Executive Officer (CEO) of Zynerba Pharmaceuticals from October 2014 until it was acquired in October 2023. Mr. Anido has more than 30 years of executive, operational and commercial leadership experience in the biopharmaceutical industry. Prior to Zynerba, Mr. Anido served as CEO of two publicly traded companies. Most recently, he was the CEO of NuPathe Inc., which was acquired by Teva Pharmaceuticals in February 2014. At NuPathe, he led the company through FDA approval of its lead product, Zecuity®, the first transdermal patch for migraine, to pre-launch before the company’s acquisition by Teva. He also served as President and CEO of Auxilium Pharmaceuticals, a specialty pharmaceutical company acquired by Endo Pharmaceuticals, Inc. in January 2015. Under Mr. Anido’s leadership at Auxilium, sales grew from $42 million in 2005 to more than $260 million in 2011. Prior to Auxilium, Mr. Anido served as Executive Vice President, Sales and Marketing, at MedImmune, where Synagis, an anti-viral for RSV, became a blockbuster product, and prior to that, in senior sales and marketing positions at GlaxoWellcome and Lederle Laboratories. At Lederle, he was Vice President, Anti-Infectives, responsible for the commercialization of the anti-bacterials, Suprax and Zosyn. He was previously a member of the Boards of Directors of Altamira Therapeutics Ltd. (formerly Auris Medical Holding AG), Life Science PA, Adolor Corporation until it was sold to Cubist Pharmaceuticals in December 2011, and Aviragen Therapeutics, Inc. Mr. Anido earned a BS in Pharmacy and an MBA from West Virginia University.

Dr. Hanham has served as a member of the board of directors since December 2008. Prior to becoming a Founding Partner and Managing Director of BAR Capital Management in December 2013, she was a General Partner with Burrill & Company, a life sciences venture capital firm, from 2000 to 2013. From 1998 to 2000, Dr. Hanham was a co-founder and Vice President of Clinical & Regulatory Affairs at InterMune, Inc. (Nasdaq: ITMN). From 1995 to 1998, she served as the Senior Director for Oncology Product Development at Otsuka Pharmaceutical, Inc. and from 1991 to 1995 as the Medical Director for Celtrix Pharmaceuticals Inc. From 1988 to 1991, Dr. Hanham worked for Becton Dickinson and Company (Nasdaq: BDX) in both regulatory and clinical affairs for the monoclonal antibody program, and from 1984 to 1988 as a regulatory toxicologist with the Health Protection Branch of Health and Welfare Canada. Dr. Hanham was previously a member of the boards of directors of HTG Molecular Diagnostics Inc., Acusphere Inc., Biomimetic Therapeutics Inc., Biotie Therapies Corp., Immunicon Corp., Targacept Inc., TLC, and Endocyte, Inc. Dr. Hanham holds a Ph.D. from the University of British Columbia, an MSc from Simon Fraser University, and a BSc from the University of Toronto. She was also Board Certified in Toxicology in 1986.

Mr. Hastings joined the board in September 2015. Mr. Hastings has served as Chief Financial Officer of Trevi Therapeutics, Inc. (Nasdaq: TRVI), a publicly-traded biopharmaceutical company, since January 2026. Prior to Trevi, he served as the Chief Financial Officer at Arbutus Biopharma Corp. (Nasdaq: ABUS) from June 2018 to March 2025. Prior to joining Arbutus, Mr. Hastings served as the Senior Vice President and Chief Financial Officer of Unilife Corporation from February 2015 to June 2017. From October 2003 to October 2014, he served as Executive Vice President and Chief Financial Officer at Incyte Corporation (Nasdaq: INCY). From February 2000 to September 2003, Mr. Hastings served as Vice President, Chief Financial Officer and Treasurer of ArQule, Inc. (Nasdaq: ARQL). Prior to his employment with ArQule and from June 1997 to February 2000, Mr. Hastings was Vice President and Corporate Controller at Genzyme, Inc. (Nasdaq: GENZ), where he was responsible for the management of the finance department. Prior to his employment with Genzyme and from May 1994 to June 1997, Mr. Hastings was the Director of Finance at Sepracor, Inc., where he was primarily responsible for Sepracor’s internal and external reporting. He previously served as a member of the board of directors of VBL Therapeutics (Nasdaq: VBLT) and Entasis Therapeutics Holdings Inc. Mr. Hastings received his B.A. in Economics at the University of Vermont.

Mr. Tinmouth joined our Board in December 2019. He has been a Partner at Flagship Pioneering since September 2025. Prior to Flagship, Mr. Tinmouth served as a Senior Advisor of Mammoth Biosciences, Inc., a biotechnology company, from March 2025 through December 2025 and previously served as Chief Business and Strategy Officer from December 2022 through February 2025. From November 2021 through December 2022, Mr. Tinmouth served as Chief Business and Strategy Officer of Pardes Biosciences (Nasdaq: PRDS), a publicly-traded biopharmaceutical company. From October 2002 through March 2020, Mr. Tinmouth served in various positions at Vertex Pharmaceuticals (Nasdaq: VRTX), a publicly traded biopharmaceutical company, most recently serving as Vice President and Head of Business Development & Alliance Management. During his career at Vertex Pharmaceuticals Incorporated, Mr. Tinmouth led or managed teams leading the company’s business transactions, yielding multiple clinical candidates and upfront cash of nearly $1B. Prior to joining Vertex in 2002, Mr. Tinmouth was a Senior Manager in the Boston office of Bain & Company, where he advised both Fortune 50 pharmaceutical companies and smaller biotechnology companies on growth strategies. Mr. Tinmouth has served as a mentor and advisor to biotech start-ups through both the Harvard Innovation Lab (Harvard iLab) and the Canadian Technology Accelerator. Early in his career, Mr. Tinmouth was a design engineer at Bombardier Aerospace, where he was a member of the flight test team for the Canadair Regional Jet. He holds a Master’s Degree in Business Administration from Harvard Business School and a Bachelor’s Degree with Honors in Mechanical Engineering from Queen’s University in Canada.

Dr. Angulo became President and Chief Executive Officer of SCYNEXIS, as well as a member of the Board of Directors, in January 2023. Dr. Angulo joined SCYNEXIS in 2015 as Chief Medical Officer. An infectious disease specialist with more than 20 years of experience in successful drug development, he previously served as Vice President, Research and Development of Brickell Biotech, Inc.

Prior to joining Brickell, Dr. Angulo held various senior positions at Stiefel Laboratories, Inc., a GSK company, including head of the clinical and medical departments. Dr. Angulo was also responsible for several development programs in the anti-infectives area at Schering-Plough Research Institute and was an infectious disease physician in a pediatric hospital. He received his medical degree from the Universidad de Guadalajara, Mexico, and has post-graduate degrees in pediatrics and infectious diseases.

Dr. Burke joined our Board in September 2026. Dr. Burke brings more than 30 years of industry experience, with a particular focus on drug development for chronic kidney disease. He has worked at Akebia Therapeutics, Inc. since 2019, and has served as its Senior Vice President, Chief Research and Development Officer and Chief Medical Officer since 2021. During his time, he has had a leadership role in the development of Vafseo® (vadadustat) for anemia due to chronic kidney disease and has supported Auryxia® (ferric citrate). He also oversees development programs for glomerular diseases and other investigational programs. Prior to joining Akebia, Dr. Burke founded Abfero Pharmaceuticals, Inc. and served on its board through its acquisition by Pharmacosmos A/S. Earlier in his career, Dr. Burke served as Senior Vice President and Chief Medical Officer of Proteon Therapeutics, Inc. from 2006 to 2019 and in senior positions at several other biotechnology companies including Genzyme Inc. Dr. Burke received an A.B. from Harvard College and an M.D. from Cornell University Medical School. He completed a residency and fellowship at Brigham and Women’s Hospital and is board certified in internal medicine and gastroenterology and has maintained a Massachusetts medical license since 1989.